Top of page Megathyrsus maximus was formerly known as Panicum maximum, placed in a subgenus of Panicum, within the grass subfamily Panicoideae. This subfamily includes over species, approximately of them in the polymorphic and polyphyletic genus Panicum. The taxonomy is somewhat confused because of the size and diversity of the Panicum genus.
Sources Fenugreek seeds and extract comes from the plant Trigonella foenum-graecum L and has been used historically for various uses such as antispasmodic, appetite stimulant, high cholesterol, wounds, blood cleanser, and expectorant effects.
Composition Trigonella foenum-graecum seeds Fenugreek seeds; the main active component of this plant tend to contain: Trigonelline, a betaine molecule also found in high levels in alfalfa and coffee  4-hydroxyisoleucine  and its precursor, 2-oxoglutarate.
Soluble fibers as galactomannins with a galactose: This may be related to the trigenolline content in part although there may be a more potent molecule able to inhibit MAO-A in the ethanolic extract 3.
Cholinergic Neurotransmission An in vitro study using crude fenugreek extract noted acetylcholinesterase inhibitory properties  with an IC50 value between 9. Momordica charantia research papers least one study has noted a preferential switch of appetite away from dietary fatty acids 3.
Absorption In the intestines, the fiber component of fenugreek seeds can suppress uptake of cholesterol and bile acids.
Absorption Fenugreek as a whole can attenuate the absorption of carbohydrates by acting as an alpha-amylase and maltase inhibitor starch and maltose digestive enzymes, respectively.
Mechanisms It has been noted that the steroidal saponins per se do not possess significant influence on glucose metabolism  and that de-gumming Fenugreek removing soluble fibers reduces the ability of Fenugreek to attenuate post-prandial blood glucose spikes.
Pancreas A protective effect on pancreatic beta-cells has been noted with fenugreek seed ingestion in diabetic rats  which has been noted with the isolated steroidal saponin content. Interventions One study using fenugreek at 2,mg twice a day for 3 months noted no changes to blood sugars or blood lipids in healthy individuals, but a reduction in blood sugar in persons with Type II diabetes and a reduction in blood lipid parameters cholesterol and triglycerides in persons with both Coronary Artery Disease and diabetes.
Skeletal Muscle When administered at mg and in conjunction with 3. Glycogen A review  notes its pluripotent effects of the above in addition to activating muscular uptake of glucose by activating PI3K, an intermediate in insulin signalling. Possible androgenic effects independent of testosterone, although no evidence exists to support the notion that this is at all a powerful androgenic effect if it is replicated Fenugreek has once been shown at mg brand name Testofen to increase serum testosterone over a period of 8 weeks in resistance trained males relative to placebo experiencing a decline in testosterone relative to baseline  although another study which noted a decrease in DHT, a testosterone metabolite failed to find any significance influence on total or free testosterone using similar methodology  and a study using mg of Testofen for a period of 6 weeks in otherwise healthy man has similarly failed to find an increase in testosterone.
One study, comparing Fenugreek to Silymarin, suggest the potency is not remarkable either 9. Lactation Fenugreek is a commonly recommended herb for increasing milk production in pregnant women,  and is seen by some as one of the few herbs with promising evidence.
The mechanism of action is not specifically known, but may be related to phytoesteogens or diosgenin. Breast Enhancement Fenugreek is sometimes used as a breast enhancing substance;  there is no evidence to support this notion.
Menopause Fenugreek has traditionally and currently via non-medical associations been recommended as a treatment for menopause with regard to lessening vaginal dryness;  there is currently insufficient evidence to support these claims.
Arcabose Arcabose is an alpha-glucosidase inhibitor that is used for treatment of diabetes by attentuating the release of glucose into the blood. Fenugreek Gum the soluble fiber aspectfenugreek is able to increase the release of arcabose from being fully absorbed in one hour and delay complete absorption for up to 8 hours, suggesting that fenugreek gum can enhance intestinal half-life.
The aromatic in fenugreek, sotolon, may be used as a diagnostic criteria for MSUD as it exists in the urine of those persons with this metabolic defect and gives the characteristic sweet-scent.Notes on Taxonomy and Nomenclature Top of page. Megathyrsus maximus was formerly known as Panicum maximum, placed in a subgenus of Panicum, within the grass subfamily regardbouddhiste.com subfamily includes over species, approximately of them in the polymorphic and polyphyletic genus Panicum.P.
maximum was the sole . Fenugreek is a plant supplemented for its libido enhancing and anti-diabetic effects. Our evidence-based analysis features 92 unique references to scientific papers.
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